Measure Affinity and Kinetics in Real Time from Your Bench SPR assays are a gold standard in biologics research and development of safe and effective treatments against disease. The data derived from SPR can aid us in better understanding molecular mechanisms while providing inishgt into key signaling pathways and advancing drug development. Join us for this…
Downloads Ultra-fast semiconductor device and thin-film characterization in 3D at the nanoscale (PDF, 212 KB) Atomic Force Microscope (AFM) can be used to look at a variety of microfabricated devices ranging from microfluidics and photonics crystals to semiconductor devices. With the nGauge AFM, it is possible to easily obtain a three-dimensional image of the sample…
Downloads Polymers and composite research using Atomic Force Microscope (PDF, 500 KB) The nGauge Atomic Force Microscope (AFM) is a power tool for characterization of polymers and composites. In three clicks, the nGauge is able to provide both topographical and mechanical data with high spatial accuracy. Topography data is straightforward—this data is gathered by scanning…
Understanding the signaling pathways that the biomarkers can activate can help in the development of check-point immunotherapies. Surface Plasmon Resonance (SPR), is a common technique used to identify and elucidate biomarker interactions, signaling pathways, mechanism of interaction, drug discovery and development of therapeutics by providing a label-free, real-time method of determining binding kinetics and binding…
Downloads Detection of Pressure-Induced Aggregation Using Microfluidic Modulation Spectroscopy (MMS) (PDF, 1 MB) Pressure-Induced Protein Aggregation Detection: Protein aggregation is a recognized signal of instability and can lead to the loss of protein function. It is therefore crucial to detect protein aggregation early in the drug development process to inform further drug development decisions. Pressure,…
Downloads Delineating the conformational landscape of the adenosine A2A receptor during G protein coupling (PDF, 9 MB) G-protein-coupled receptors (GPCRs) represent a ubiquitous membrane protein family and are important drug targets. Their diverse signaling pathways are driven by complex pharmacology arising from a conformational ensemble rarely captured by structural methods. Here, fluorine nuclear magnetic resonance spectroscopy (19F NMR) is used to delineate key…
Downloads Biosimilar Comparison and Accelerated Stability Predictions Based on <2% Secondary Structure Differences Using Microfluidic Modulation Spectroscopy (MMS) (PDF, 1 MB) Biosimilar molecules are designed to mimic innovator molecules that have been approved and are available on the market, providing others within the industry an opportunity to create structurally similar therapeutic medicines for greater patient…
Existing tools for measuring and monitoring the structure of biotherapeutic molecules during formulation have had until now very significant limitations in sensitivity and have been very difficult to use. In this webinar, Amgen shares data that demonstrates the power of Microfluidic Modulation Spectroscopy (MMS), a novel, fully-automated IR technology, to generate high-quality, reproducible secondary structure…
Downloads Energy Storage Devices Undergo Endurance Testing by Binder (PDF, 2 MB) Battery Test Chambers are used for endurance tests to characterize the cyclic and chronological aging of cells and modules for lithium batteries, as well as their aging under varying environmental conditions in order to determine the service life and performance of these components…
Creating a battery material with optimum power production and energy storage will require control of the particle size distribution of the electrode materials. Laser diffraction is a widely used technique for measuring particles size distributions for materials across a wide range of industries. Date recorded: November 5, 2019 Batteries are used in an increasing range of…