Delineating the conformational landscape of the adenosine A2A receptor during G protein coupling
Downloads Delineating the conformational landscape of the adenosine A2A receptor during G protein coupling (PDF, 9 MB) G-protein-coupled receptors (GPCRs) represent a ubiquitous membrane protein family and are important drug targets. Their diverse signaling pathways are driven by complex pharmacology arising from a conformational ensemble rarely captured by structural methods. Here, fluorine nuclear magnetic resonance spectroscopy (19F NMR) is used to delineate key…
