Downloads Ultra-fast semiconductor device and thin-film characterization in 3D at the nanoscale (PDF, 212 KB) Atomic Force Microscope (AFM) can be used to look at a variety of microfabricated devices ranging from microfluidics and photonics crystals to semiconductor devices. With the nGauge AFM, it is possible to easily obtain a three-dimensional image of the sample…
With SARS-CoV2, many people were left wondering about the need for multiple shots, whereas certain vaccines, such as the vaccine for yellow fever, require only one shot in our lifetime. In short, it’s due to a combination of escape variants and dropping levels of antibodies allows for reinfection. A full explanation can be found here: Some…
Downloads Polymers and composite research using Atomic Force Microscope (PDF, 500 KB) The nGauge Atomic Force Microscope (AFM) is a power tool for characterization of polymers and composites. In three clicks, the nGauge is able to provide both topographical and mechanical data with high spatial accuracy. Topography data is straightforward—this data is gathered by scanning…
Today’s lab is a high data throughput environment. Nearly all of your equipment is capturing data, and key analytical systems are capturing more data than ever before. As the pace, volume and variety of data increase, the use of analytics has become essential to creating operational efficiencies
Understanding the signaling pathways that the biomarkers can activate can help in the development of check-point immunotherapies. Surface Plasmon Resonance (SPR), is a common technique used to identify and elucidate biomarker interactions, signaling pathways, mechanism of interaction, drug discovery and development of therapeutics by providing a label-free, real-time method of determining binding kinetics and binding…
Downloads Detection of Pressure-Induced Aggregation Using Microfluidic Modulation Spectroscopy (MMS) (PDF, 1 MB) Pressure-Induced Protein Aggregation Detection: Protein aggregation is a recognized signal of instability and can lead to the loss of protein function. It is therefore crucial to detect protein aggregation early in the drug development process to inform further drug development decisions. Pressure,…
Downloads Delineating the conformational landscape of the adenosine A2A receptor during G protein coupling (PDF, 9 MB) G-protein-coupled receptors (GPCRs) represent a ubiquitous membrane protein family and are important drug targets. Their diverse signaling pathways are driven by complex pharmacology arising from a conformational ensemble rarely captured by structural methods. Here, fluorine nuclear magnetic resonance spectroscopy (19F NMR) is used to delineate key…
Downloads Biosimilar Comparison and Accelerated Stability Predictions Based on <2% Secondary Structure Differences Using Microfluidic Modulation Spectroscopy (MMS) (PDF, 1 MB) Biosimilar molecules are designed to mimic innovator molecules that have been approved and are available on the market, providing others within the industry an opportunity to create structurally similar therapeutic medicines for greater patient…
There is a growing emphasis on having more sustainable and environment-conscious electric vehicles (EV) around the world. The transport sector currently accounts for about 17 percent of global greenhouse gas emissions. Hence, stimulating supply and demand for EV adoption in the mass market will be pivotal to meet both local emission goals and international climate…
Existing tools for measuring and monitoring the structure of biotherapeutic molecules during formulation have had until now very significant limitations in sensitivity and have been very difficult to use. In this webinar, Amgen shares data that demonstrates the power of Microfluidic Modulation Spectroscopy (MMS), a novel, fully-automated IR technology, to generate high-quality, reproducible secondary structure…