The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to be a global health concern. At the time of writing, the number of diagnosed cases around the world has exceeded 194 million with Asia recording over 60.5 million. At the end of 2020, the emergence of fast-spreading SARS-CoV-2 mutant strains…
Despite its impressive growth in recent years, the EV lithium-ion battery (LIB) industry still has some catching up to do to reach the levels of maturity of consumer battery manufacturing and the mainstream automotive industry. There are many varieties of materials and electrochemical couples available in the present lithium-ion battery market. Many manufacturers are designing…
The ubiquitin proteasome system (UPS) is the body’s built-in garbage recycling system. Its function is to degrade unwanted, used, or misfolded proteins back into amino acids, and scientists have recently found a way to use this to fight against cancer. The newly popularized small molecule proteolysis-targeting chimeras (PROTACs) acts on the UPS by tagging cancerous…
Antibody drug conjugates (ADCs) are attracting a tremendous amount of attention because they have the potential to revolutionize cancer treatment. Chemical ligation of cytotoxic agents to monoclonal antibodies allows the selective delivery of cytotoxins to tumor cells thereby potentially mitigating some of the damaging side-effects of cancer chemotherapy. There are currently nine FDA-approved ADCs and…
Ever-more structurally complex bio-molecules and biological entities are coming into focus within the pharma development space, with fit-for-purpose analytics becoming more important to their success. Reducing development time and optimising formulation through applying orthogonal analytical technologies is key to bringing them to market in an efficient, risk-free manner. Date recorded: June 22, 2021 In addition…
Bispecific antibodies are promising therapeutics for targeting cancer cells with high specificity. The measurement of binding rates and avidity effects in the simultaneous engagement of two antigens by a bispecific antibody is key for understanding and optimizing target selectivity early in the drug development process. The quantitative analysis of individual and cooperative target binding, as…
Microplastics are extremely small pieces of plastic particles measuring up to five millimeters in size. Present in commercial product development and the breakdown of larger plastics, they include one or a combination of the following polymers: polyethylene, polypropylene, polyvinyl chloride, polyamide, polystyrene, and polyethylene terephthalate. They can be found in commercial products like cosmetics, clothing,…
We live in an aging society. Medical standards continue to develop and medicine is constantly evolving as scientists carry out research into new drugs. More and more people require medication and cases of polymedication, where people need to take numerous different types of medicine every day, are becoming more common. The long road from development…
A Laboratory Information Management System (LIMS) helps researchers effectively manage the flow of samples and produce better test data. The benefits offered to laboratory teams include increased productivity, reduced deviations, faster closure times, reduced investigation workloads, and savings on operation costs. As human resources take up to 75 percent of a lab’s total operational costs,…
At present, the atomic force microscope (AFM) is among the most effective imaging techniques used at the nanoscale and sub-nanoscale levels. It is an imaging and measurement method that has become a very important and popular tool for nanoscale research and industrial research and development activities. The use of AFMs is growing among companies requiring…