Bispecific antibodies are promising therapeutics for targeting cancer cells with high specificity. The measurement of binding rates and avidity effects in the simultaneous engagement of two antigens by a bispecific antibody is key for understanding and optimizing target selectivity early in the drug development process. The quantitative analysis of individual and cooperative target binding, as…
Microplastics are extremely small pieces of plastic particles measuring up to five millimeters in size. Present in commercial product development and the breakdown of larger plastics, they include one or a combination of the following polymers: polyethylene, polypropylene, polyvinyl chloride, polyamide, polystyrene, and polyethylene terephthalate. They can be found in commercial products like cosmetics, clothing,…
Measure Affinity and Kinetics in Real Time from Your Bench SPR assays are a gold standard in biologics research and development of safe and effective treatments against disease. The data derived from SPR can aid us in better understanding molecular mechanisms while providing inishgt into key signaling pathways and advancing drug development. Join us for this…
We live in an aging society. Medical standards continue to develop and medicine is constantly evolving as scientists carry out research into new drugs. More and more people require medication and cases of polymedication, where people need to take numerous different types of medicine every day, are becoming more common. The long road from development…
A Laboratory Information Management System (LIMS) helps researchers effectively manage the flow of samples and produce better test data. The benefits offered to laboratory teams include increased productivity, reduced deviations, faster closure times, reduced investigation workloads, and savings on operation costs. As human resources take up to 75 percent of a lab’s total operational costs,…
With SARS-CoV2, many people were left wondering about the need for multiple shots, whereas certain vaccines, such as the vaccine for yellow fever, require only one shot in our lifetime. In short, it’s due to a combination of escape variants and dropping levels of antibodies allows for reinfection. A full explanation can be found here: Some…
Today’s lab is a high data throughput environment. Nearly all of your equipment is capturing data, and key analytical systems are capturing more data than ever before. As the pace, volume and variety of data increase, the use of analytics has become essential to creating operational efficiencies
Understanding the signaling pathways that the biomarkers can activate can help in the development of check-point immunotherapies. Surface Plasmon Resonance (SPR), is a common technique used to identify and elucidate biomarker interactions, signaling pathways, mechanism of interaction, drug discovery and development of therapeutics by providing a label-free, real-time method of determining binding kinetics and binding…
Downloads Detection of Pressure-Induced Aggregation Using Microfluidic Modulation Spectroscopy (MMS) (PDF, 1 MB) Pressure-Induced Protein Aggregation Detection: Protein aggregation is a recognized signal of instability and can lead to the loss of protein function. It is therefore crucial to detect protein aggregation early in the drug development process to inform further drug development decisions. Pressure,…
Downloads Delineating the conformational landscape of the adenosine A2A receptor during G protein coupling (PDF, 9 MB) G-protein-coupled receptors (GPCRs) represent a ubiquitous membrane protein family and are important drug targets. Their diverse signaling pathways are driven by complex pharmacology arising from a conformational ensemble rarely captured by structural methods. Here, fluorine nuclear magnetic resonance spectroscopy (19F NMR) is used to delineate key…