Read on to learn about the two most common approaches for measuring binding kinetics, multi-cycle kinetics (MCK) and single-cycle kinetics (SCK), and how to select the right one for your interaction.
Nanoparticle Tracking Analysis (NTA) with the Particle Metrix ZetaView® instrument family allows fast and reliable measurement of size, concentration, and Zeta Potential of nanoparticles. In contrast to scatter-based particle detection, fluorescence detection capability of the ZetaView® instrument allows the user to get biochemical information about particles. This increases the resolution and discriminatory power of the data. Furthermore,…
Ever-more structurally complex bio-molecules and biological entities are coming into focus within the pharma development space, with fit-for-purpose analytics becoming more important to their success. Reducing development time and optimising formulation through applying orthogonal analytical technologies is key to bringing them to market in an efficient, risk-free manner. Date recorded: June 22, 2021 In addition…
The term “pH” is derived from either “pondus hydrogenii” or “potentia hydrogenii”. Both are originally Latin phrases, with “pondus hydrogenii” meaning “weight of hydrogen” and “potentia hydrogenii” meaning “power of hydrogen”. The pH value is a non-dimensional number that measures how acidic or alkaline an aqueous solution is. It is defined as the negative decimal…
Bispecific antibodies are promising therapeutics for targeting cancer cells with high specificity. The measurement of binding rates and avidity effects in the simultaneous engagement of two antigens by a bispecific antibody is key for understanding and optimizing target selectivity early in the drug development process. The quantitative analysis of individual and cooperative target binding, as…
Microplastics are extremely small pieces of plastic particles measuring up to five millimeters in size. Present in commercial product development and the breakdown of larger plastics, they include one or a combination of the following polymers: polyethylene, polypropylene, polyvinyl chloride, polyamide, polystyrene, and polyethylene terephthalate. They can be found in commercial products like cosmetics, clothing,…
Measure Affinity and Kinetics in Real Time from Your Bench SPR assays are a gold standard in biologics research and development of safe and effective treatments against disease. The data derived from SPR can aid us in better understanding molecular mechanisms while providing inishgt into key signaling pathways and advancing drug development. Join us for this…
We live in an aging society. Medical standards continue to develop and medicine is constantly evolving as scientists carry out research into new drugs. More and more people require medication and cases of polymedication, where people need to take numerous different types of medicine every day, are becoming more common. The long road from development…
A Laboratory Information Management System (LIMS) helps researchers effectively manage the flow of samples and produce better test data. The benefits offered to laboratory teams include increased productivity, reduced deviations, faster closure times, reduced investigation workloads, and savings on operation costs. As human resources take up to 75 percent of a lab’s total operational costs,…
At present, the atomic force microscope (AFM) is among the most effective imaging techniques used at the nanoscale and sub-nanoscale levels. It is an imaging and measurement method that has become a very important and popular tool for nanoscale research and industrial research and development activities. The use of AFMs is growing among companies requiring…